TrueCrypt 5.0 has been released. Among the new features are the ability to encrypt a system partition or entire system drive (i.e. a drive where Windows is installed) with pre-boot authentication, pipelined operations increasing read/write speed by up to 100%, Mac OS X version, graphical interface for the Linux version, XTS mode, SHA-512, and more.

After four years of development, during which millions of people downloaded a copy of TrueCrypt, it is the only open-source disk encryption software that runs on Windows, Mac OS X, and Linux. The newly implemented ability to encrypt system partitions and system drives provides the highest level of security and privacy, as all files, including any temporary files that Windows and applications create on system drives (typically, without the user’s knowledge or consent), swap files, etc., are permanently encrypted. Large amounts of potentially sensitive data that Windows records, such as the names and locations of files opened by the user, applications that the user runs, etc., are always permanently encrypted as well.

For more information,

Please See http://www.truecrypt.org/docs/?s=version-history

Free open-source disk encryption software for Windows Vista/XP , Mac OS X, and Linux
Main Features:

Source : True Crypt

My Guide : Ultimate TrueCrypt Guide : Create And Mount Virtual Encrpyted Partitions

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